Treating gender as an environmental factor and testing associations for interaction with gender is one way of identifying associations modified by gender. A significant interaction may indicate either variable strength of the associations, or opposite direction of the associations in males and females. Analysis after stratification by gender clarifies the situation, and unravels any gender-specificity which may otherwise go unnoticed, especially if the association is with decreased risk in one gender, and with increased risk in the other.
Wikipedia People who develop abnormally frequent cases of a skin cancer known as basal cell carcinoma appear to be at significantly increased risk for the development of other cancers, including blood, breast, colon and prostate cancers, according to a preliminary study by researchers at the Stanford University School of Medicine.
The increased susceptibility is likely caused by mutations in a panel of proteins responsible for repairing DNA damage, the researchers found. Medical student Hyunje Cho is the lead author. Largest organ The skin is the largest organ of the body and the most vulnerable to DNA damage caused by the sun's ultraviolet rays.
Try as one might, it's just not possible to completely avoid sun exposure, which is why proteins that repair DNA damage are important to prevent skin cancers like basal cell carcinoma.
Most of the time this system works well. But sometimes the repair team can't keep up. Basal cell carcinomas are common—more than 3 million cases a year are diagnosed in the United States alone—and usually highly treatable.
Sarin and Cho wondered whether the skin could serve as a kind of canary in the coal mine to reveal an individual's overall cancer susceptibility.
They investigated whether these people may have mutations in 29 genes that code for DNA-damage-repair proteins. That's shockingly high," Sarin said. Furthermore, 21 of the 61 people reported a history of additional cancers, including blood cancer, melanoma, prostate cancer, breast cancer and colon cancer—a prevalence that suggests the frequent basal cell carcinoma patients are three times more likely than the general population to develop cancers.
Over 13, people in the database had six or more basal cell carcinomas; these people also were over three times more likely to have developed other cancers, including colon, melanoma and blood cancers. Finally, the researchers identified an upward trend: Now we can ask patients with repeated basal cell carcinomas whether they have family members with other types of cancers, and perhaps suggest that they consider genetic testing and increased screening.
They'd also like to conduct a similar study in patients with frequent melanomas. But they emphasized that there's no reason for people with occasional basal cell carcinomas to worry. If, however, you've been diagnosed with several basal cell carcinomas within a few years, you may want to speak with your doctor about whether you should undergo increased or more intensive cancer screening.
Common skin cancer can signal increased risk of other cancers, researchers sayAugust 9 retrieved 16 January from https: Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission.
The content is provided for information purposes only.Sarin and Cho wondered whether the skin could serve as a kind of canary in the coal mine to reveal an individual's overall cancer susceptibility. "The skin is basically a walking mutagenesis. Ludwig Institute for Cancer Research Summary: Researchers have uncovered how a genetic variation present in ethnic groups from around the equator may influence cancer susceptibility.
Unlike most editing & proofreading services, we edit for everything: grammar, spelling, punctuation, idea flow, sentence structure, & more. Get started now! Scienctific Opinions on Susceptibility to Skin Cancer ( words, 6 pages) This paper is going to be about skin cancer and if you are more likely to get skin cancer by Tanning Beds or Ultraviolet rays, is there any data proving that tanning bed and ultraviolet ray are equally bad.
This paper is going to be about skin cancer and if you are more likely to get skin cancer by Tanning Beds or Ultraviolet rays, is there any data proving that tanning bed and ultraviolet ray are equally bad.
There is a lot of data that proves any Ultraviolet rays can give you skin cancer. Yo. In those with mutations in the breast cancer susceptibility genes BRCA1 or BRCA2, The most common form of cancer is non-invasive non-melanoma skin cancer; resulted in the widespread acceptance of second opinions before surgery, less invasive surgical procedures, support groups.